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■神経疾患とドレブリン機能
興奮性シナプスのアクチン結合タンパク−その動態と機能−
スパインのアクチン細胞骨格は興奮性シナプス形成を制御する
蛋白レベルからみた神経シナプスの発達と異常
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ドレブリン
ドレブリンは神経系の代表的なアクチン結合蛋白で、我々のグループにより発見された蛋白です。興味のある方は是非ご一読ください。
リンク

2012年度 (金曜日午後5時から)
日時
担当
紹介論文
3.15 安田

Dopamine neurons modulate neural encoding and expression of depression-related behaviour

3.1 Reni

Cranial Irradiation Alters Dendritic Spine Density and morphology in the Hippocampus

2.15 六本木 Activity-Dependent Spine Morphogenesis: A Role for the Actin-Capping Protein Eps8
2.1 清水

LTP-Induced Long-Term Stabilization of Individual Nascent Dendritic Spines Travis C. Hill and Karen Zito The Journal of Neuroscience, 9 January 2013, 33(2): 678-68

1.18 梶田 Sarah A. Roberts, et al., “Pheromonal Induction of Spatial Learning in Mice” Science 338, 1462 (2012)
1.11 小金澤

Nat Neurosci. 2012 Dec;15(12):1700-6.             Optical controlling reveals time-dependent roles for adult-born dentate granule cells.Gu Y, Arruda-Carvalho M, Wang J, Janoschka SR, Josselyn SA, Frankland PW, Ge S.

12.14 石塚 J Neurosci.(2012, 32(48), 17401-17406
"Depression of Hippocampal Long-Term Potentiation Is Mediated through the Amylin Receptor"
Kimura R, Mactavish D, Yang J, Westaway D, Jhamandas JH
11.30 山崎

Cell (2012), 151 , 709-723                 “Pathogenic SYNGAP1 Mutations Impair Cognitive Development by Disrupting Maturation of Dendritic Spine Synapses”James P. Clement, Massimiliano Aceti, Thomas K. Creson, Emin D. Ozkan, Yulin Shi, 3 Nicholas J. Reish, Antoine G. Almonte, Brooke H. Miller, Brian J. Wiltgen, Courtney A. Miller, Xiangmin Xu, and Gavin Rumbaugh

11.16 安田 Anhedonia requires MC4R-mediated synaptic adaptations in nucleus accumbens Byung Kook Lim, Kee Wui Huang, Brad A. Grueter, Patrick E. Rothwell & Robert C. Malenka
Nature 
487,183?189, 2012 (12 July 2012)
11.2 児島

Coba et al. "TNiK Is Required for Postsynaptic and Nuclear Signaling Pathways and Cognitive Function."  J Neurosci 32:13987-13999, 2012.

10.26 六本木

Nerupharmacology (2008), 55, 175-182 “5-HT2 receptor-mediated reversal of the inhibition of hippocampal long-term potentiation by acute inescapable stress” Benedict K. Ryan, Roger Anwyl, Michael J. Rowan

10.19 大原

Activity-dependent Growth of New Dendritic Spines Is Regulated by the Proteasome Andrew M. Hamilton, Won Chan Oh, Hugo Vera-Ramirez, Ivar S. Stein, Johannes W. Hell, Gentry N. Patrick, and Karen Zito Neuron 74, 1023-1030, 2012

10.12 Reni

Karolina Roughton, Marie Kalm and Klas Blomgren Sex dependent differences in behavior and hippocampal neurogenesis after irradiation to the young mouse brain. European Journal of Neuroscience, Vol. 36, pp. 2763?2772, 2012

10.5 清水

K. W. Miyazaki, K. Miyazaki, K. Doya,             Activation of Dorsal Raphe Serotonin Neurons Is Necessary for Waiting for Delayed Rewards, The Journal of Neuroscience (2012) 32(31): 10451-10457

9.14 梶田

Masayuki Sakamoto, et al., "Continuous neurogenesis in the adult forebrain is required for innate olfactory responses"Proc Natl Acad Sci U S A. 17: 8479-84 (2011)

9.7 小金澤

Nat Neurosci. 2012 Jul 15;15(8):1153-9.          Dissecting spatial knowledge from spatial choice by hippocampal NMDA receptor deletion.Bannerman DM, Bus T, Taylor A, Sanderson DJ, Schwarz I, Jensen V, Hvalby O, Rawlins JN, Seeburg PH, Sprengel R.

7.27 石塚

Neuron (2012), 74, 277-284.“Regulation of Presynaptic Neurotransmission by Macroautophagy”Hernandez D, Torres CA, Setlik W, Cebri?n C, Mosharov EV, Tang G, Cheng HC, Kholodilov N, Yarygina O, Burke RE, Gershon M, Sulzer D.

7.13 山崎

Neuron (2012), 73, 1127-1142.“Chemical Genetic Identi?cation of NDR1/2 Kinase Substrates AAK1 and Rabin8 Uncovers Their Roles in Dendrite Arborization and Spine Development”Sila K. Ultanir, Nicholas T. Hertz, Guangnan Li, Woo-Ping Ge, Alma L. Burlingame, 8 Samuel J. Pleasure, Kevan M. Shokat, Lily Yeh Jan, and Yuh-Nung Jan

6.29 安田

Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function Hyejung Won, etc.Nature 486, pp.261-265 (14 June 2012)

6.22 児島

Mg2+ Block of Drosophila NMDA Receptors Is Required for Long-Term Memory Formation and CREB-Dependent Gene Expression. Miyashita et al. Neuron 74:887-898, 2012

6.15 大原 Noel C. Derecki et al. Wild-type microglia arrest pathology in a mouse model of Rett syndrome. Nature 484: 105-111 (2012)
6.1 Reni

Nature Neuroscience (2012) Advance Online Publication Hepatocyte growth factor mediates mesenchymal stem cell-induced recovery in multiple sclerosis models Lianhua Bai, Donald P Lennon, Arnold I Caplan, Anne DeChant, Jordan Hecker, Janet Kranso, Anita Zaremba & Robert H Miller

5.25 渡部

Nature neuroscience, 2012, advanced online publication Activation of adult-born neurons facilitates learning and memory.Mariana Alonso, Gabriel Lepousez, Sebastien Wagner, Cedric Bardy, Marie-Madeleine Gabellec, Nicolas Torquet & Pierre-Marie Lledo

5.18 六本木

Journal of Neurochemistry (2011) 116, 291-303       Density and function of central serotonin (5-HT) transporters, 5-HT1A and 5-HT2A receptors, and effects of their targeting on BTBR T+tf/J mouse social behavior          Georgianna G. Gould、Julie G. Hensler, Teresa F. Burke, Robert H. Benno, Emmanuel S. Onaivi and Lynette C. Daws

4.23 清水

Matthew N. Hill et al.Recruitment of Prefrontal Cortical Endocannabinoid Signaling by Glucocorticoids Contributes to Termination of the Stress Response The Journal of Neuroscience, 20 July 2011, 31(29): 10506-10515

4.16 梶田

Michelle W.M. Li, et al., “Actin-binding protein drebrin E is involved in junction dynamics during spermatogenesis"Spermatogenesis 1, 123-136 (2011)

4.9 石塚 Nature (2012), in press
"Optogenetic stimulation of a hippocampal engram activates fear memory recall"
Xu Liu, Steve Ramirez, Petti T. Pang, Corey B. Puryear, Arvind Govindarajan, Karl Deisseroth & Susumu Tonegawa
copyright 1997-2011, Department of Neurobiology and Behavior,
Gunma University Graduate School of Medicine, All rights reserved.