• When the accumulation of drebrin at postsynaptic site is inhibited, PSD-95 is not clustered.
  • Takahashi, H., Sekino, Y., Tanaka S., Mizui, T., Kishi, S, and Shirao, T., .
    "Drebrin-dependent actin clustering in dendritic filopodia governs synaptic targeting of postsynaptic density-95 and dendritic spine morphogenesis."
    J Neurosci 23(16): 6586-6595.(2003)
    
    
• Supression of drebrin expression inhibit PPI (prepulse inhibiton of startled reflex)
  • Kobayashi R, Sekino Y, Shirao T, Tanaka S, Ogura T, Inada K, and Saji M.
    "Antisense knockdown of drebrin A, a dendritic spine protein, causes stronger preference, impaired pre-pulse inhibition, and an increased sensitivity to psychoostimulant." Neurosci. Res 49:205-217(2004)
    
    
• New splice variant of drebrin is found.
  • Jin, M., Tanaka, S., Sekino, Y., Ren, Y., Yamazaki, H., Kawai-Hirai, R., Kojima and Shirao, T.
    "A novel, brain-specific mouse drebrin: cDNA cloning, chromosomal mapping, genomic structure, expression, and functional characterization."
    Genomics 79(5): 686-692.(2002)

• Drebrin binds to connexin and activate the GAP junction.
  • Butkevich E, Huelsmann S, Wenzel D, Shirao T, Duden R, Majoul I.
    "Drebrin is a novel Connexin-43 binding partner thant links gap junctions to the submembrane cytoskeleton."
    Curr. Biol. 14:650-658(2004)

• Impairment of learning and meory in Alzheimer disease is in paralleled with the decrease of drebrin expression.
  • Calon F, Lim GP, Yang F, Morihara T, Teter B, Ubeda O, Rostaing P, Triller A, Salem N Jr, Ashe KH, Frautschy SA, Cole GM.
    Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model.
    Neuron. 2004 Sep 2;43(5):633-45.

• Other papers related to drebrin decrease in Alzheimer disease.
  • Harigaya,Y., Shoji,M., Shirao,T. and Hirai,S.
    "Disappearance of actin-binding protein, drebrin, from hippocampal synapses in Alzheimer's disease."
    J Neurosci Res 43(1): 87-92.(1996).
    
  • Hatanpaa,K., Isaacs,K,R., Shirao,T., DR. Brady. and Rapoport,S,I.
    "Loss of proteins regulating synaptic plasticity in normal aging of the human brain and in Alzheimer disease."
    J Neuropathol Exp Neurol 58(6): 637-643.(1999)
    
  • Shim KS, Lubec G.
    Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome.
    Neurosci Lett. 2002 May 24;324(3):209-12.

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