Real original 4 papers of drebrin

• Drebrin E's (as S5 and S6 proteins) were first identified as developmentally regulated brain protein by two-dimensional gel electrophoresis.
  • Shirao, T. and K. Obata
    "Two acidic proteins associated with brain development in chick embryo."
    J Neurochem 44(4): 1210-1216.(1985).
    
• Drebrin A (as S54 protein) was discocovered using monoclonal antibody raiseed against drebrin E.
  • Shirao, T. and K. Obata .
    "Immunochemical homology of 3 developmentally regulated brain proteins and their developmental change in neuronal distribution."
    Brain Res 394(2): 233-244 .(1986)
    
• Drebrin A (as S54 proteins) was shown to be neuron-specific protein in dendrites.
  • Shirao,T., Inoue,H,K., Kano,Y. and Obata,K.
    "Localization of a developmentally regulated neuron-specific protein S54 in dendrites as revealed by immunoelectron microscopy."
    Brain Res 413(2): 374-378.(1987).
    
• The name of drebrin was first used in this paper.
  • Shirao,T., Kojima,N., Kato,Y. and Obata,K.
    "Molecular cloning of a cDNA for the developmentally regulated brain protein, drebrin."
    Brain Res 464(1): 71-74.(1988).
    

Papers of cDNA cloning of drebrin

• Chicken drebrin E's
  • Kojima,N., Kato,Y., Shirao,T. and Obata,K.
    "Nucleotide sequences of two embryonic drebrins, developmentally regulated brain proteins, and developmental change in their mRNAs."
    Brain Res 464(3): 207-215. (1988).
    
• Chicken drebrin A and alternative splicing
  • Kojima,N.,Shirao,T.and Obata,K.
    "Molecular cloning of a developmentally regulated brain protein, chicken drebrin A and its expression by alternative splicing of the drebrin gene."
    Brain Res Mol Brain Res 19(1-2): 101-114.(1993).
    
• Rat drebrin A
  • Shirao, T., Kojima,N. and Obata,K.
    "Cloning of drebrin A and induction of neurite-like processes in drebrin-transfected cells."
    Neuroreport 3(1): 109-112.(1992).
    
• Human drebrin E and chromosome mapping
  • Toda, M., Shirao, T., Minoshima, S., Shimizu, N., Toya, S. and Uyemura,k.
    "Molecular cloning of cDNA encoding human drebrin E and chromosomal mapping of its gene."
    Biochem Biophys Res Commun 196(1): 468-472.(1993).
    

Drebrin E is observed both in non-neuornal and neuronal cells. Drebrin A is observed only in neurons. Drebrin E activity is related in cell adhesion and cell polarity.

• Keon BH, Jedrzejewski PT, Paul DL, Goodenough DA "Isoform specific expression of the neuronal F-actin binding protein, drebrin, inspecialized cells of stomach and kidney epithelia." J Cell Sci113: 325-336 (2000)
• Peitsch WK, Grund C, Kuhn C, Schnolzer M, Spring H, Schmelz M, Franke WW "Drebrin is a widespread actin-associating protein enriched at junctional plaques, defining a specific microfilament anchorage system in polar epithelial cells." Eur J Cell Biol 78:767-78 (1999)
  

Expression of exogenous GFP-drebrin A is spontanuosly accumulated within spines and elongate the length of spine (neck and head). This is the first demonstration in the world showing that the change of one protein expression can affect the spine shape.

• Hayashi, K. and T. Shirao
  "Change in the shape of dendritic spines caused by overexpression of drebrin in cultured cortical neurons."
  J Neurosci 19(10): 3918-3925.(1999)
  
• Shirao,T., Hayashi,K., Ishikawa,R., Isa, K., Asada, H., Ikeda,K. and Uyemura,K.
  "Formation of thick, curving bundles of actin by drebrin A expressed in fibroblasts."
  Exp Cell Res 215(1): 145-153.(1994).
  
• Shirao, T., Kojima,N. and Obata,K.
  "Cloning of drebrin A and induction of neurite-like processes in drebrin-transfected cells."
  Neuroreport 3(1): 109-112.(1992).
  

Drebrin is one of the member of proteins containing ADF homology domain.

• P. Lappalainen, MM Kessels, MJTV Cope, and DG Drubin "The ADF homology (ADF-H) domain: A Highly exploited actin-binding module." Mol. Biol. Cell 9: 1951-1959 (1998)
  

SH3P7 (ABP1) has a homology to drebrin.

• Yamazaki,H., Takahashi,H., Aoki,T. and Shirao,T. .
  "Molecular cloning and dendritic localization of rat SH3P7."
  Eur J Neurosci 14(6): 998-1008.(2001)
  
• O. Larbolette, B Wollscheid, J Schweikert, PJ Nielsen, and J Wienands "SH3P7 is a cytoskeleton adapter protein and is coupled to signal transduction from lymphocyte antigen receptors." Mol. Cell. Biol. 19: 1539-1546 (1999)
• AB Sparks, NG Hoffman, SJ McConnell, DM Fowlkes and BK Kay "Cloning of ligand targets: Systematic isolation of SH3 domain-containing proteins." Nature Biotech. 14: 741-744 (1996)
  

Transient ischmic shock induce the rapid decrease of drebrin in the hippocampus.-1647（1995）

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