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Drebrin

Classical papers of drebrin

  • Shirao,T and Obata,K.”Two acidic proteins associated with brain development in chick embryo.”  J. Neurochem. 44: 1210-1216. (1985) (Original discovery of drebrin in chicken brain)
  • Shirao,T and  Obata,K. “Immunochemical homology of 3 developmentally regulated brain proteins and their developmental change in neuronal distribution.”  Dev. Brain Res. 29: 233-244  (1986)
  • Shirao,T.,  Inoue,H.K.,  Kano ,Y. and  Obata,K. “Localization of a developmentally regulated neuron-specific protein S54 in dendrites as revealed by immunoelectron microscopy.”  Brain Res. 413: 374-378  (1987)
  • Shirao,T., Kojima,N.,  Kato,Y. and  Obata,K. “Molecular cloning of a cDNA for the developmentally regulated brain protein, drebrin.”  Mol.Brain Res. 4: 71-74  (1988) (Naming of drebrin)
  • Kojima,N., Kato,Y., Shirao,T. and Obata,K “Nucleotide sequences of two embryonic drebrins, developmentally regulated brain proteins, and developmental change in their mRNAs.”  Mol. Brain Res 4: 207-215  (1988) (Sequence of drebrin E's in chicken brain)
  • Shirao,T.,Kojima,N., Nabeta,Y., and Obata,K.  “Two forms of drebrins, developmentally regulated brain proteins, in rat.”  Proc.Japan Acad 65: 169-172  (1989) (Original paper for mammalian drebrin)
  • Shirao,T., Kojima,N. and Obata,K “Cloning of drebrin A and induction of neurite-like processes in drebrin-transfected cells.”  NeuroReport 3: 109-112  (1992) (Clonign of drebrin A)
  • Imamura, K.,Shirao,T.,  Mori ,K.and Obata,K. “Changes of drebrin expression in the visual cortex of the cat during development.”  Neurosci.Res  13: 33-41 (1992) (drebrin and synaptic plasticity)
  • Kojima,N., Shirao,T. and Obata,K “Molecular cloning of a developmentally regulated brain protein chicken drebrin A and its expression by alternative splicing of the drebrin gene” Mol. Brain Res.19: 101-114  (1993) (Alternative splicing from adrebrin gene)
  • Toda,M., Shirao,T., Minoshima,S., Shimizu ,N., Toya,S. and Uyemura,K.”Molecular cloning of cDNA encoding the actin-binding protein, human drebrin E and Chromosomal mapping of drebrin gene #.”  Biochem.Biophys.Res.Commu. 196: 468-472 (1993) (Clonign of human drebrin)
  • Asada,H., Uyemura,K. and Shirao,T. “Actin-binding protein, drebrin, accumulates in submembranous regions in parallel with neuronal differentiation.”  J. Neurosci. Res. 38: 149-159 (1994) (Discovery of actin-binding activity of drebrin)
  • Shirao,T., Hayashi,K., Ishikawa,R., Isa,K., Asada,H., Ikeda,K. and Uyemura,K. “Formation of thick curving bundles of actin by drebrin A expressed in fibroblasts.” Exp. Cell Res. 215:145-153 (1994) (Drebrin modulates actin bundle)
  • Ishikawa,R.,  Hayashi,K., Shirao,T., Xue,Y., Takagi,T., Sasaki,Y. and  Kohama,K. “Drebrin, a development-associated brain protein from rat embryo, causes the dissociation of tropomyosin from actin filaments” J. Biol. Chem. 269:29928-29933 (1994) (First analysis of biochemical data of actin-binding activity of drebrin)
  • Ikeda,K., Shirao,T., Toda,M., Asada,H., Toya,S. and Uyemura,K. “Effect of neuron-specific actin-binding protein, drebrin A, on cell-substratum adhesion.” Neurosci. Lett. 194, 197-200 (1995) (derbrin and adhesion plaque)
  • Kobayashi,S., Isa,K., Hayashi,K., Inoue,H.K., Uyemura,K. and Shirao,T. “K252a, a potent inhibitor of protein kinases, inhibits the migration of cerebellar granule cells in vitro” Dev. Brain Res. 90: 122-128 (1995) (drebrin and cell migration)
  • Harigaya, Y., Shoji,M., Shirao,T., and Hirai,S. “Disappearance of actin-binding protein, drebrin, from hippocampal sysnapses in Alzheimer’s Disease.” J. Neurosci. Res. 43: 87-92 (1996) (Original discovery of drebrin decrease in Alzheimer disease)
  • Ikeda,K., Kaub,P.A., Asada,H., Uyemura,K.,  Toya,S. and Shirao,T. “Stabilization of adhesion plaques by the expression of drebrin A in fibroblasts.” Dev.Brain Res. 91: 227-236 (1996)
  • Sasaki,Y., Hayashi,K., Shirao,T., Ishikawa,R. and Kohama,K “Inhibition by drebrin of the actin-binding activity of brain fascin, a protein localized in filopodia of growth cones.”  J. Neurochem.66: 980-988 (1996)
  • Hayashi,K., Ishikawa,R., Li-Hong,Y.,  HE,X., Takata,K., Kohama,K. and Shirao,T. “Modulatory role of drebrin on the cytoskeleton within dendritic spines in rat cerebral cortex.” J. Neurosci. 15: 7161-7170 (1996)
  • Mammoto,A., Sasaki,T., Asakura,T., Hotta,I., Imamura,H., Takahashi,K., Matsura,Y., Shirao,T., Takai,Y. “Interactions of drebrin and gephyrin with profilin.” Biochem. Biophys. Res. Commun. 243: 86-89 (1998)
  • Hayashi,K., Suzuki,K., and Shirao,T. “ Rapid conversion of drebrin isoforms during synapse formation in primary culture of cortical neurons.”  Devel. Brain Res. 111: 137-141 (1998)
  • Toda,M., Shirao,T. and Uyemura,K. “Suppression of an actin-binding protein, drebrin, by antisense transfection inhibits neurite outgrowth in neuroblastoma B104 cells” Devl. Brain Res. 114: 193-200 (1999)
  • Hayashi ,K.and Shirao,T. “Change in the shape of dendritic spines caused by overexpression of drebrin in cultured cortical neurons” J. Neurosci. 19: 3918-3925 (1999) (drebrin and dendritic spine morphology)
  • Hatanpaa, K., Isaacs, K.R., Shirao, T., Brady, DR. and Rapoport, S.I.” Aging of the human brain: Loss of synaptic proteins regulating plasticity.”  J. Neuropathol. and Exp. Neurol. 58: 637-643 (1999)
  • Hayashi K, Ishikawa R, Kawai-Hirai R, Takagi T, Taketomi A ,Shirao T “Domaoin ananlysis of the actin-binding and actin-remodeling activities of drebrin.” Experimental Cell Research 253: 673-680 (1999)
  • Cheng,X-T., Hayashi,K. and Shirao,T. “Non-muslcle myosin IIB-like immunoreactivity is present at the drebrin ?binding cytoskeleton in neurons” Neurosci. Res. 36: 167-173 (2000).
  • Yamazaki,H., Takahashi,H., Aoki,T. and Shirao,T. “Molecular Cloning and Dendritic Localization of rat SH3P7” Eur. J. Neurosci. 14: 998-1008 (2001) (First identified drebrin homologue)
  • Kobayashi,S., Shirao,T., and Sasaki,T. “Drebrin expression is increased in spinal motoneurons after axotomy.” Neuorsci. Lett. 311: 165-168 (2001)
  • Jin, Mi., Tanaka,S., Sekino,Y., Ren,Y., Yamazaki,H., Kawai-Hirai,R., Kojima,N. and Shirao,T. “A Novel Brain-Specific Mouse Drebrin: cDNA Cloning, Chromosomal Mapping, Genomic Structure, Expression, and Functional Characterization” Genomics 79:686-692 (2002)
  • Takahashi, H., Sekino, Y., Tanaka S., Mizui, T., Kishi, S, and Shirao, T., “Drebrin-dependent Actin Clustering in Dendritic Filopodia Governs Synaptic Targeting of Postsynaptic Density-95 and Dendritic Spine Morphogenesis” J. Neurosci. 23:6586?6595 (2003)
  • Kobayashi,R., Sekino,Y., Shirao,T., Tanaka,S., Ogura,T., Inada,K., and Saji,M. “Antisense knockdown of drebrin A, a dendritic spine protein, causes stronger preference, impaired pre-pulse inhibition, and an increased sensitivity to psychostimulant.” Neurosci. Res.49:205-217 (2004)
  • Butkevich, E., Huelsmann,S., Wenzel, D., Shirao,T., Duden, R., and Majoul, I. , “Drebrin is a novel Connexin-43 binding partner that links gap junctions to the submembrane cytoskeleton.” Curr. Biol. 14:650-658 (2004)
  • Aoki, C., Sekino, Y., Hanamura, K., Fujisawa, S., Mahadomrongkul, V., Ren, Y., and Shirao, T. “Drebrin A is a Postsynaptic Protein that Localizes in vivo to the Submembranous Surface of Dendritic Sites Forming Excitatory Synapses” J. Comp. Neurol. 483: 383-402 . (2005 )(EM-IHC study of drebrin A)

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