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2017年

論文

小金澤紀子、花村健次、白尾智明、「ヒトiPS細胞由来神経細胞を用いた医薬品評価系の現状について」日本薬理学雑誌 149: 104-109 (2017)

Shirao T, Hanamura K, Koganezawa N, Ishizuka Y, Yamazaki H, Sekino Y. "The role of drebrin in neurons" . J. Neurochem. (2017) 141(6):819-834. doi: 10.1111/jnc.13988. Epub 2017 Apr 21. Review. (Free Acess)

Koganezawa N, Hanamura K, Sekino Y, Shirao T. "The role of drebrin in dendritic spines" Mol Cell Neurosci. 2017 Oct;84:85-92. doi: 10.1016/j.mcn.2017.01.004.(Open Access)

Li B, Ding S, Feng N, Mooney N, Ooi YS, Renf L, Diep J, Kelly MR, Yasukawa LL, Patton JT, Yamazaki H, Shirao T, Jackson PK, Greenberg HB.  "Drebrin restricts rotavirus entry by inhibiting dynamin-mediated endocytosis." Proc Natl Acad Sci U S A, (2017) Apr 17. pii: 201619266. doi: 10.1073/pnas.1619266114.

Kajita Y, Kojima N, Koganezawa N, Yamazaki H, Sakimura K, Shirao T. “Drebrin E regulates neuroblast proliferation and chain migration in the adult brain Eur J Neurosci. 2017 Sep;46(6):2214-2228.

Hanamura K, Washburn HR, Sheffler-Collins SI, Xia NL, Henderson N, Tillu DV, Hassler S, Spellman DS, Zhang G, Neubert TA, Price TJ, Dalva MB Extracellular phosphorylation of a receptor tyrosine kinase controls synaptic localization of NMDA receptors and regulates pathological pain.PLoS Biol. 2017 Jul 18;15(7):e2002457.

Shirao T., Sekino Y. (Eds.) (2017) Drebrin. (Advances in Experimental Medicine and Biology, vol 1006) Tokyo, Springer

Sekino Y, Koganezawa N, Mizui T, Shirao T. “Role of Drebrin in Synaptic Plasticity” Adv Exp Med Biol. 2017;1006:183-201. doi: 10.1007/978-4-431-56550-5_11.

Yamazaki H, Shirao T. “Homer, Spikar, and Other Drebrin-Binding Proteins in the Brain”Adv Exp Med Biol. 2017;1006:249-268. doi: 10.1007/978-4-431-56550-5_14

Shirao T, Koganezawa N, Yamazaki H, Hanamura K, Imamura K. “Localization of Drebrin: Light Microscopy Study” Adv Exp Med Biol. 2017;1006:105-118. doi: 10.1007/978-4-431-56550-5_7

Shirao T, Sekino Y. “General Introduction to Drebrin” Adv Exp Med Biol. 2017;1006:3-22. doi: 10.1007/978-4-431-56550-5_1.

Ishizuka Y, Hanamura K. “Drebrin in Alzheimer's Disease” Adv Exp Med Biol. 2017;1006:203-223. doi: 10.1007/978-4-431-56550-5_12.

Hanamura K. “Drebrin in Neuronal Migration and Axonal Growth” Adv Exp Med Biol. 2017;1006:141-155. doi: 10.1007/978-4-431-56550-5_9.

 

国際学会

The 7th International Society of Radiation Neurobiology Conference, 2017, Shuchuan Miao, Noriko Koganezawa, Tomoaki Shirao “Effects of 10 Gy X-irradiation on hippocampal postsynaptic proteins in vivo and in vitro.” Yuzawa, Japan February 9-10.

The 7th International Society of Radiation Neurobiology Conference, 2017, Takero Oka, Kenji Hanamura, Noriko Koganezawa, Kazumi Kamiyama, Natsume Tanaka, Tomoaki Shirao “High-content imaging analysis of glutamatergic synapses using primary cultured neurons. Yuzawa, Japan February 9-10.

The 7th International Society of Radiation Neurobiology Conference, 2017, Noriko Koganezawa, Tomoaki Shirao “Nanoscale organization of synaptic proteins: super-resolution imaging study.” Yuzawa, Japan February 9-10.

JCS Journal Meeting, Cellular dynamics: membrane-cytoskeleton interface. Shirao T, Hanamura K. 2017 “Role of drebrin isoform conversion in synapse formation” Southbridge, MA, USA May 21-24

Fifth International Symposium on Space Radiation and Particle Radiotherrapy, 2017, Puspitasari A, Koganezawa N, Shirao T, Kojima N, Held KD, Takahashi A, Nakano T. “Acute effects of low-LET and high-LET radiation on fear memory formation and its underlying mechanisms” Suzhou, China, May 24-26.

The 38th World Congress of the International Union of Physiological Sciences (IUPS),. Tomoaki Shirao and Yuko Sekino, 2017 “Novel actin-dependent mechanism of synaptic plasticity” in Symposium "Cellular and molecular aspects of synaptic transmission"Rio De Janeiro, Brazil, August 1-5

The 38th World Congress of the International Union of Physiological Sciences (IUPS),Sunchuan Miao, Noriko Koganezawa, Kenji Hanamura,  Tomoaki Shirao  NMDA receptors are associated with X-irradiation-induced acute synaptic dysfunction of hippocampal neurons in vitro and in vivo. . Rio De Janeiro, Brazil, August 1-5

The 10th Congress on Alternatives and Animal Use in the Life Sciences, Shirao T, Hanamura K, Konganezawa N, Yamazaki H, Sekino Y. “An imaging assay to analyze primary hippocampal neurons for cellular maturation” Seattle, WA, USA, August 20-24

The 17th Annual Meeting of Safety Pharmacology Society. Shirao T, Puspitasari A, Koganezawa N, Kawamura H, Takahashi A, Sekino Y, Nakano T, Held KD, 2017, “In vivo and in vitro immunochemical assay for CNS synaptic dysfunction by X-irradiation” Berlin, Germany September 23-25.

The 63rd Annual Meeting of Radiation Research Society. Koganezawa N, Puspitasari A, Miao S, Nakano T, Shirao T. 2017, “Transient synaptic dysfunction caused by X-irradiation induces acute cognitive deficits” in the Symposium “Radiation neurobiology: from basic science to the clinic” Cancun, Mexico, October 15-18, 2017

The 63rd Annual Meeting of Radiation Research Society.Puspitasari A, Koganezawa N, Shirao T, Kojima N, Held KD, Takahashi A, Nakano T. “Acute effects of low-LET and high-LET radiation on fear memory formation and its underlying mechanisms” Cancun, Mexico, October 15-18, 2017

Society for Neuroscience 46th Annual Meeting, 2017, Shirao T, Hanamura K, Yasuda H, Sekino Y, Kojima N. “Drebrin plays a role in mGluR5-dependent LTD” Washington, DC, USA, November 11-15.

Society for Neuroscience 46th Annual Meeting, 2017, Koganezawa N., Shirao T. “Super-resolution imaging of synaptic proteins” Washington, DC, USA, November 11-15.

Society for Neuroscience 46th Annual Meeting, 2017, Puspitasari A, Koganezawa N, Held KD, Shirao T, Nakano T. “The cells and cells communication may underlie radiation-induced synaptic dysfunction of mature neurons” Washington, DC, USA, November 11-15.

国内学会

岡 丈朗、花村 健次、白尾 智明 「培養神経細胞を用いたハイコンテントイメージングによるシナプスの解析」第90回日本薬理学会年会、長崎、2017年3月15日

Miao, S., Koganezawa, N., Shirao, T. 「Underlying mechanism of radiotoxicity effects on synaptic proteins」第90回日本薬理学会年会、長崎、2017年3月15日

清水英雄、小針彩奈、須知由未子、関口敬洋、花村健次、白尾智明、田辺光男、関野祐子、佐藤薫 「ベンゾジアゼピン系薬剤の培養海馬神経細胞シナプス数に対する作用―医薬品の中枢神経系有害反応予測のための新規 in vitro 評価系確立の試み」第90回日本薬理学会年会、長崎、2017年3月17日

Noriko Koganezawa, Yukai Chiu and Tomoaki Shirao 「Nanoscale organization of synaptic proteins」日本神経科学学会、幕張、2017年7月20日~23日

Kojima N, Yasuda H, Sakimura K, Shirao T 「Impact of drebrin-knockout on mGluR5- and NMDAR-dependent LTD induction in the hippocampus」日本神経科学学会、幕張、2017年7月20日~23日

Noriko Koganezawa and Tomoaki Shirao 「Differential changes of drebrin and PSD-95 localization in response to glutamate stimulation」第60回日本神経化学会大会、仙台、2017年9月7日~9日

Hiroyuki Yamazaki, Noriko Koganezawa, Tomoaki Shirao 「Super-resolution analysis of the interaction between drebrin and CaMKIIbeta in dendritic spines」第60回日本神経化学会大会、仙台、2017年9月7日~9日

Kenji Hanamura, Tomoaki Shirao 「Isoform-dependent regulation of drebrin dynamics in dendritic spines」、第60回日本神経化学会大会、仙台、2017年9月7日~9日

白尾智明「ヒト神経細胞を用いた病態モデルづくり」、第60回日本神経化学大会・AMED再生医療実用化研究事業「創薬のためのインビトロ脳機能評価法の確立と標準化ヒト神経細胞の開発」事業・一般公開シンポジウム「アルツハイマー病のクスリ創り~病気の理解と病態モデル~」、仙台、2017年9月9日

Anggraeini Puspitasari1, Hidemasa Kawamura2, Hiroyuki Yamazaki3, Yukari Yoshida, Akihisa Takahashi, Tomoaki Shirao, Takashi Nakano, Kathryn D Held, “Irradiation of immature neurons causes delayed decreases in the number of neurons and postsynaptic protein drebrin” The 31st Annual Meeting, Japanese Society for Biological Sciences in Space (JSBSS), 前橋、2017年9月20日

 

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