脳科学を超えた新しい学問分野を創設する

Achievements

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Publications

  • Anggraeini P, Koganezawa N, Kojima N., Tanaka N, Nakano T, Shirao T “X-irradiation induces acute cognitive decline via transient synaptic dysfunction.” Rad. Res. 185, 423–430 (2016)
  • Kojima K, Yasuda H, Hanamura K, Ishizuka Y, Sekino Y, Shirao T. “Drebrin A regulates hippocampal LTP and hippocampus-dependent fear learning in adult mice” Neuroscience. 324: 218–226 (2016)

International Conference

Society for Neuroscience 45th Annual Meeting, 2016, Noriko Koganezawa and Tomoaki Shirao “Developmental regulation of NMDA receptor subunits expression by drebrin” San Diego, USA, November 12-16

The 62nd Annual International Meeting of Radiation Research Society Tomoaki Shirao, Anggraeini Puspitasari, Takashi Nakano and Noriko Koganezawa. “X-irradiation induces acute cognitive decline via actin reorganization in dendritic spines.” Big Island, HI, USA, October 16-19, 2016

The 62nd Annual International Meeting of Radiation Research Society. Permata TBM, Sato H, Puspitasari A, Koganezawa N, Noda S, Shirao T, Nakano T. “Irradiation effects on drebrin expression in cervical cancer.” Big Island, HI, USA, October 16-19, 2016

The 5th Annual Meeting of the ASCCT. Tomoaki Shirao, Yuta Ishizuka, Kenji Hanamura, Yasunari Kanda and Yuko Sekino, “Quantitative imaging analysis of amyloid beta toxicity using cultured neurons.” Durham, NC, USA, September 29-30.

The 16th Annual Meeting of Safety Pharmacology Society. Tomoaki Shirao. “Immunohistochemical assay for CNS synaptic disfunction using cultured neurons.” in the symposium “Immunohistochemical Assay for Central Nervous System Synaptic Dysfunction Using Cultured Neurons.” (invited) Vancouver, BC, Canada, September 18-21, 2016

The 10th FENS Forum of Neuroscience, 2016, Noriko Koganezawa, Shuchuan Miao, Yuko Sekino, Tomoaki Shirao “Nanoscale organization of synaptic proteins revealed by super-resolution imaging.” Copenhagen, Denmark July 2-6

The 10th FENS Forum of Neuroscience, 2016, Shuchuan Miao, Anggraeini Puspitasari, Noriko Koganezawa, Natsume Tanaka, Tomoaki Shirao. “The acute process of X-irradiation-induced decrease in drebrin clusters within dendritic spines of cultured hippocampal neurons is associated with NMDA receptor activity.” Copenhagen, Denmark July 2-6

The 10th FENS Forum of Neuroscience, 2016, Tomoaki Shirao and Yuta Ishizuka “Amyloid beta induced drebrin loss from synapses via histone deacetylase activity.” Copenhagen, Denmark July 2-6

.The 7th ISN 2016 Special Conference of Neurochemistry, 2016, Tomoaki Shirao, Yuko Sekino, Hiroyuki Yamazaki. “CaMKIIβ is localized in dendritic spines as both drebrin-dependent and drebrin-independent pools.” Coimbra, Portugal, June 1-4.

The 55th Annual Meeting of Society of Toxicology, Tomoaki Shirao, Noriko Koganezawa, Yuta Ishizuka, Hiroyuki Yamazaki, Kenji Hanamura, Yuko Sekino “Toxic Effects of Astemizole on Neurite Growth and Synaptogenesis of CNS neurons” New Orleans LA, USA, March 13-17.

The 6th International Society of Radiation Neurobiology Conference, 2016, Anggraeini Puspitasari “Irradiation effects on higher brain function with low and high LET radiation” (5th ISRN Best Poster Award Presentation), Nagasaki, Japan, February 12-13

The 6th International Society of Radiation Neurobiology Conference, 2016, Shuchuan Miao, Kenji Hanamura, Anggraeini Puspitasari, Noriko Koganezawa, Tomoaki Shirao. “NMDA receptors are involved in X-irradiation-induced decrease in drebrin clusters within dendritic spines of cultured hippocampal neurons in vitro.” Nagasaki, Japan, February 12-13

The 6th International Society of Radiation Neurobiology Conference, 2016, Noriko Koganezawa, Yuki Kajita, Kenji Sakimura, Tomoaki Shirao. “Primary cultured hippocampal neurons prepared from drebrin knockout mice show the less immunoreactivity of MAP2 and NMDA subunits.” Nagasaki, Japan, February 12-13

The 6th International Society of Radiation Neurobiology Conference, 2016, Takashi Hiruma, Noriko Koganezawa, Puspitasari Anggraeini, Tomoaki Shirao. “HDAC inhibitors prevent synaptic dysfunction elicited by X-irradiation.” Nagasaki, Japan, February 12-13

Society for Neuroscience 45th Annual Meeting, 2016, Noriko Koganezawa and Tomoaki Shirao “Developmental regulation of NMDA receptor subunits expression by drebrin” San Diego, USA, November 12-16

The 5th Annual Meeting of the ASCCT. Tomoaki Shirao, Yuta Ishizuka, Kenji Hanamura, Yasunari Kanda and Yuko Sekino, “Quantitative imaging analysis of amyloid beta toxicity using cultured neurons.” Durham, NC, USA, September 29-30.

The 16th Annual Meeting of Safety Pharmacology Society. Tomoaki Shirao. “Immunohistochemical assay for CNS synaptic disfunction using cultured neurons.” in the symposium “Immunohistochemical Assay for Central Nervous System Synaptic Dysfunction Using Cultured Neurons.” (invited) Vancouver, BC, Canada, September 18-21, 2016

The 10th FENS Forum of Neuroscience, 2016, Noriko Koganezawa, Shuchuan Miao, Yuko Sekino, Tomoaki Shirao “Nanoscale organization of synaptic proteins revealed by super-resolution imaging.” Copenhagen, Denmark July 2-6

The 10th FENS Forum of Neuroscience, 2016, Shuchuan Miao, Anggraeini Puspitasari, Noriko Koganezawa, Natsume Tanaka, Tomoaki Shirao. “The acute process of X-irradiation-induced decrease in drebrin clusters within dendritic spines of cultured hippocampal neurons is associated with NMDA receptor activity.” Copenhagen, Denmark July 2-6

The 10th FENS Forum of Neuroscience, 2016, Tomoaki Shirao and Yuta Ishizuka “Amyloid beta induced drebrin loss from synapses via histone deacetylase activity.” Copenhagen, Denmark July 2-6

.The 7th ISN 2016 Special Conference of Neurochemistry, 2016, Tomoaki Shirao, Yuko Sekino, Hiroyuki Yamazaki. “CaMKIIβ is localized in dendritic spines as both drebrin-dependent and drebrin-independent pools.” Coimbra, Portugal, June 1-4.

The 55th Annual Meeting of Society of Toxicology, Tomoaki Shirao, Noriko Koganezawa, Yuta Ishizuka, Hiroyuki Yamazaki, Kenji Hanamura, Yuko Sekino “Toxic Effects of Astemizole on Neurite Growth and Synaptogenesis of CNS neurons” New Orleans LA, USA, March 13-17.

The 6th International Society of Radiation Neurobiology Conference, 2016, Anggraeini Puspitasari “Irradiation effects on higher brain function with low and high LET radiation” (5th ISRN Best Poster Award Presentation), Nagasaki, Japan, February 12-13

The 6th International Society of Radiation Neurobiology Conference, 2016, Shuchuan Miao, Kenji Hanamura, Anggraeini Puspitasari, Noriko Koganezawa, Tomoaki Shirao. “NMDA receptors are involved in X-irradiation-induced decrease in drebrin clusters within dendritic spines of cultured hippocampal neurons in vitro.” Nagasaki, Japan, February 12-13

The 6th International Society of Radiation Neurobiology Conference, 2016, Noriko Koganezawa, Yuki Kajita, Kenji Sakimura, Tomoaki Shirao. “Primary cultured hippocampal neurons prepared from drebrin knockout mice show the less immunoreactivity of MAP2 and NMDA subunits.” Nagasaki, Japan, February 12-13

The 6th International Society of Radiation Neurobiology Conference, 2016, Takashi Hiruma, Noriko Koganezawa, Puspitasari Anggraeini, Tomoaki Shirao. “HDAC inhibitors prevent synaptic dysfunction elicited by X-irradiation.” Nagasaki, Japan, February 12-13

Society for Neuroscience 45th Annual Meeting, 2016, Noriko Koganezawa and Tomoaki Shirao “Developmental regulation of NMDA receptor subunits expression by drebrin” San Diego, USA, November 12-16

The 10th FENS Forum of Neuroscience, 2016, Noriko Koganezawa, Shuchuan Miao, Yuko Sekino, Tomoaki Shirao “Nanoscale organization of synaptic proteins revealed by super-resolution imaging.” Copenhagen, Denmark July 2-6

The 10th FENS Forum of Neuroscience, 2016, Shuchuan Miao, Anggraeini Puspitasari, Noriko Koganezawa, Natsume Tanaka, Tomoaki Shirao. “The acute process of X-irradiation-induced decrease in drebrin clusters within dendritic spines of cultured hippocampal neurons is associated with NMDA receptor activity.” Copenhagen, Denmark July 2-6

The 10th FENS Forum of Neuroscience, 2016, Tomoaki Shirao and Yuta Ishizuka “Amyloid beta induced drebrin loss from synapses via histone deacetylase activity.” Copenhagen, Denmark July 2-6

.The 7th ISN 2016 Special Conference of Neurochemistry, 2016, Tomoaki Shirao, Yuko Sekino, Hiroyuki Yamazaki. “CaMKIIβ is localized in dendritic spines as both drebrin-dependent and drebrin-independent pools.” Coimbra, Portugal, June 1-4.

The 55th Annual Meeting of Society of Toxicology, Tomoaki Shirao, Noriko Koganezawa, Yuta Ishizuka, Hiroyuki Yamazaki, Kenji Hanamura, Yuko Sekino “Toxic Effects of Astemizole on Neurite Growth and Synaptogenesis of CNS neurons” New Orleans LA, USA, March 13-17.

The 6th International Society of Radiation Neurobiology Conference, 2016, Anggraeini Puspitasari “Irradiation effects on higher brain function with low and high LET radiation” (5th ISRN Best Poster Award Presentation), Nagasaki, Japan, February 12-13

The 6th International Society of Radiation Neurobiology Conference, 2016, Shuchuan Miao, Kenji Hanamura, Anggraeini Puspitasari, Noriko Koganezawa, Tomoaki Shirao. “NMDA receptors are involved in X-irradiation-induced decrease in drebrin clusters within dendritic spines of cultured hippocampal neurons in vitro.” Nagasaki, Japan, February 12-13

The 6th International Society of Radiation Neurobiology Conference, 2016, Noriko Koganezawa, Yuki Kajita, Kenji Sakimura, Tomoaki Shirao. “Primary cultured hippocampal neurons prepared from drebrin knockout mice show the less immunoreactivity of MAP2 and NMDA subunits.” Nagasaki, Japan, February 12-13

The 6th International Society of Radiation Neurobiology Conference, 2016, Takashi Hiruma, Noriko Koganezawa, Puspitasari Anggraeini, Tomoaki Shirao. “HDAC inhibitors prevent synaptic dysfunction elicited by X-irradiation.” Nagasaki, Japan, February 12-13

The 6th International Society of Radiation Neurobiology Conference, 2016, Anggraeini Puspitasari “Irradiation effects on higher brain function with low and high LET radiation” (5th ISRN Best Poster Award Presentation), Nagasaki, Japan, February 12-13

The 6th International Society of Radiation Neurobiology Conference, 2016, Shuchuan Miao, Kenji Hanamura, Anggraeini Puspitasari, Noriko Koganezawa, Tomoaki Shirao. “NMDA receptors are involved in X-irradiation-induced decrease in drebrin clusters within dendritic spines of cultured hippocampal neurons in vitro.” Nagasaki, Japan, February 12-13

The 6th International Society of Radiation Neurobiology Conference, 2016, Noriko Koganezawa, Yuki Kajita, Kenji Sakimura, Tomoaki Shirao. “Primary cultured hippocampal neurons prepared from drebrin knockout mice show the less immunoreactivity of MAP2 and NMDA subunits.” Nagasaki, Japan, February 12-13

The 6th International Society of Radiation Neurobiology Conference, 2016, Takashi Hiruma, Noriko Koganezawa, Puspitasari Anggraeini, Tomoaki Shirao. “HDAC inhibitors prevent synaptic dysfunction elicited by X-irradiation.” Nagasaki, Japan, February 12-13

The 55th Annual Meeting of Society of Toxicology, Tomoaki Shirao, Noriko Koganezawa, Yuta Ishizuka, Hiroyuki Yamazaki, Kenji Hanamura, Yuko Sekino “Toxic Effects of Astemizole on Neurite Growth and Synaptogenesis of CNS neurons” New Orleans LA, USA, March 13-17.

 

 

Domestic Conference

石塚 佑太、山崎博幸、白尾 智明「グリアアセンブリにおけるDrebrin-connexin 43相互作用に関する研究」第59回日本神経化学会大会、福岡、2016年9月8日~10日

清水英雄、小針彩奈、須知由未子、関口敬洋、花村健次、白尾智明、田辺光男、関野祐子、佐藤薫、「シナプスイメージングに基づき医薬品の認知機能影響リスクを予測する in vitro 評価系確立の試み」第59回日本神経化学会大会、福岡、2016年9月8日~10日

Hiroyuki Yamazaki, Yuki Arayama, Yuta Ishizuka, Kaoru Sato, Yuko Sekino, Tomoaki Shirao 「Thrombospondin-1 induces an axon formation in early developmental stage of human iPS cell-derived neuron」第39回日本神経科学大会2016年7月20日~22日

Noriko Koganezawa and Tomoaki Shirao 「Drebrin regulates expression pattern of NMDA receptor subunits」第39回日本神経科学大会2016年7月20日~22日

花村健次、白尾 智明 「スパイン内のドレブリンの安定性は発達期のアイソフォーム変換によりアクチン細胞骨格依存的に増加する」第39回日本神経科学大会2016年7月20日~22日

白尾智明「培養神経細胞を用いた認知症モデルとその創薬応用の可能性」 AMED 再生医療実用化建久事業 シンポジウム 培養神経細胞の可能性「医薬品開発への応用を目指したモデル細胞の構築とその応用」、千里ライフサイエンスセンター、大阪 2016年5月27日

Kenji Hanamura, Nobuhiko Kojima, Hiroki Yasuda, Hiroyuki Yamazaki, Tomoaki Shirao “Maturation of actin cytoskeleton in dendritic spines and the age-dependent role in synaptic plasticity” 第93回日本生理学会大会、札幌、2016年3月22日〜24日 (in Symposium “Molecular mechanisms underlying synapse formation and remodeling during development and age-related synaptopathy")

Tomoaki Shirao “Progress in applications of iPSC derived neurons for neuronal maturation” 第89回日本薬理学会年会、横浜、2016年3月9日~11日 (invited in Symposium “Accelerating practical applications of cutting edge human iPS cell technologies” )

Noriko Koganezawa, Shuchuan Miao, Tomoaki Shirao “Nanoscale organization of synaptic proteins in dendritic spines and shafts” 第93回日本生理学会大会、札幌、2016年3月22日~24日

 

Achievements

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