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Neuronal development and drebrin

  • Kobayashi,S., Isa,K., Hayashi,K., Inoue,H.K., Uyemura,K. and Shirao,T. “K252a, a potent inhibitor of protein kinases, inhibits the migration of cerebellar granule cells in vitro” Dev. Brain Res. 90: 122-128 (1995)
  • Sasaki,Y., Hayashi,K., Shirao,T., Ishikawa,R. and Kohama,K “Inhibition by drebrin of the actin-binding activity of brain fascin, a protein localized in filopodia of growth cones.”  J. Neurochem.66: 980-988 (1996)
  • Hayashi,K., Suzuki,K., and Shirao,T. “ Rapid conversion of drebrin isoforms during synapse formation in primary culture of cortical neurons.”  Devel. Brain Res. 111: 137-141 (1998)
  • Toda,M., Shirao,T. and Uyemura,K. “Suppression of an actin-binding protein, drebrin, by antisense transfection inhibits neurite outgrowth in neuroblastoma B104 cells” Devl. Brain Res. 114: 193-200 (1999)
  • Hayashi ,K.and Shirao,T. “Change in the shape of dendritic spines caused by overexpression of drebrin in cultured cortical neurons” J. Neurosci. 19: 3918-3925 (1999)
  • Kobayashi,S., Shirao,T., and Sasaki,T. “Drebrin expression is increased in spinal motoneurons after axotomy.” Neuorsci. Lett. 311: 165-168 (2001)
  • Takahashi, H., Sekino, Y., Tanaka S., Mizui, T., Kishi, S, and Shirao, T., “Drebrin-dependent Actin Clustering in Dendritic Filopodia Governs Synaptic Targeting of Postsynaptic Density-95 and Dendritic Spine Morphogenesis” J. Neurosci. 23:6586?6595 (2003)
  • Takahashi, H., Sekino, Y., TanakaS., Mizui, T., Kishi, S, and Shirao, T., “Drebrin-dependent Actin Clustering in Dendritic Filopodia Governs Synaptic Targeting of Postsynaptic Density-95 and Dendritic Spine Morphogenesis” J. Neurosci. 23:6586–6595 (2003)
  • Mizui, T., Sekino, Y., Takahashi, H., Yamazaki, H. and Shirao, T. “Overexpression of drebrin A in immature neurons induces the accumulation of F-actin and PSD-95 into dendritic filopodia, and the formation of large abnormal protrusions.” Mol. Cell. Neurosci.  30: 149-157(2005)
  • Takahashi, H., Mizui, T., Shirao, T. “Downregulation of drebrin A expression suppresses synaptic targeting of NMDA receptors in developing hippocampal neurons” J. Neuochem  97(Suppl.1):110-115 (2006)
  •  Song M, Kojima N, Hanamura K, Sekino Y, Inoue KH, Mikuni M, Shirao T, “Expression of drebrin E in migrating neuroblasts in adult rat brain: coincidence between drebrin E disappearance from cell body and cessation of migration” Neuroscience. 152:670-682 (2008)

  • Mizui T., Kojima N, Yamazaki H, Katayama M, Hanamura K, Shirao T. “Drebrin E is involved in the mechanism regulating axonal growth through actin-myosin interactions.” J Neurochem 109:611-622 (2009)
  • Yamazaki H, Kojima N, Kato K, Hirose H, Iwasaki T, Mizui T, Takahashi H, Hanamura K,  Roppongi RT, KoibuchiN, Sekino Y, Mori N, Shirao T. “Spikar, a novel drebrin-binding protein, regulates the formation and stabilization of dendritic spines.” J Neurochem. 128:507-522 (2014)

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