脳科学を超えた新しい学問分野を創設する

業績集

論文のリプリント(PDF)が必要な方はメール頂ければ送付します。ご連絡先はこちら

2014年

論文

  • Ishizuka Y, Shimizu H, Takagi E, Kato M, Yamagata H, Mikuni M, Shirao T. "Histone deacetylase mediates the decrease in drebrin cluster density induced by amyloid beta oligomers." Neurochem Int. 76:114-121 (2014)

  • Tanabe K, Yamazaki H, Inaguma Y, Asada A, Kimura T, Takahashi J, Taoka M, Ohshima T, Furuichi T, Isobe T, Nagata K, Shirao T,  Hisanaga S. “Phosphorylation of drebrin by cyclin-dependent kinase 5 and its role in neuronal migration.” PLoS One. 9:e92291 (2014)
  • Ishikawa M, Shiota J, Ishibashi1 Y, Hakamata T, Shoji S, Fukuchi M, Masaaki Tsuda M, Shirao T, Sekino Y, Baraban JM and Tabuchi A. “Cellular localization and dendritic function of rat isoforms of the SRF coactivator MKL1 in cortical neurons.” NeuroReport. 25:585-592 (2014)
  • Mizui T, Sekino Y, Yamazaki1, Yuta Ishizuka H, Takahashi H, Kojima N, Kojima M and ShiraoT. “Myosin II ATPase activity mediates the long-term potentiation-induced exodus of stable F-actin bound by drebrin A from dendritic spines” PLoS ONE. 9(1):e85367 (2014)
  • Yamazaki H, Kojima N, Kato K, Hirose H, Iwasaki T, Mizui T, Takahashi H, Hanamura K,  Roppongi RT, KoibuchiN, Sekino Y, Mori N, Shirao T. “Spikar, a novel drebrin-binding protein, regulates the formation and stabilization of dendritic spines.” J Neurochem. 128:507-522 (2014)
  • Kudo S, Suzuki Y, Noda S, Mizui T, Shirai K, Okamoto M, Kaminuma T, Yoshida Y, Shirao T and Nakano T. “Comparison of the radiosensitivities of neurons and glial cells derived from the same rat brain.” Exp. Ther. Med. 8: 754-758, 2014

国際学会

The 6th ISN Special Conference, 2014, T. Shirao. “Drebrin and its function” (Keynote lecture) Tokyo, Japan, September 20-22.

The 6th ISN Special Conference, 2014, H. Shimizu, Y. Ishizuka, T. Shirao. “Allopregnanolone increases the density of drebrin clusters along dendrite” Tokyo, Japan, September 20-22.

The 6th ISN Special Conference, 2014, Y. Ishizuka, H. Shimizu, T. Shirao. “Amyloid beta oligomers induce drebrin exodus from dendritic spines via histone deacetylase activation.” Tokyo, Japan, September 20-22.

The 6th ISN Special Conference, 2014, A. Puspitasari, N. Koganezawa, M. Shuchuan, N. Kojima, M. Isono, Y. Yoshida, T. Kanai, T. Shirao. “Acute effect of Carbon Ion Irradiation on hippocampal neuron and fear memory formation.” Tokyo, Japan, September 20-22.

The 6th ISN Special Conference, 2014, R.T.Roppongi, T. Shirao “5-HT2A receptor activity induces the disappearance of drebrin from dendritic spines in NMDA receptor dependent manner” Tokyo, Japan, September 20-22.

The 6th ISN Special Conference, 2014, N. Koganezawa, H. Shimizu, T. Shirao “Nanoscale organization of an actin-binding protein, drebrin” Tokyo, Japan, September 20-22.

The 6th ISN Special Conference, 2014, Y. Kajita, H. Yamazaki, N. Koganezawa, T. Shirao “Drebrin A overexpression causes structural change of microtubule via F-actin modification in cultured fibroblast” Tokyo, Japan, September 20-22.

The 6th ISN Special Conference, 2014, H. Yamazaki, T. Shirao “Spikar function and its stabilization in dendritic spines are dependent on drebrin.” Tokyo, Japan, September 20-22.

ISN Satellite Symposium “Key molecules for neuronal maturation -Application for validating the maturation of human iPSC-derived neurons -”, 2014, T Shirao “Drebrin as a surrogate marker of synaptic maturation” Tokyo, Japan, September 23

ISN Satellite Symposium “Key molecules for neuronal maturation -Application for validating the maturation of human iPSC-derived neurons -”, 2014, H Yamazaki “A novel drebrin-binding protein spikar-mediates spine formation” Tokyo, Japan, September 23

ISN Satellite Symposium “Key molecules for neuronal maturation -Application for validating the maturation of human iPSC-derived neurons -”, 2014, R T Roppongi “Early development of iPSC-derived neurons” Tokyo, Japan, September 23

Safety Pharmacology Society 14th Annual Meeting, 2014, Tomoaki Shirao, Yuta Ishizuka, Hideo Shimizu and Yuko Sekino “Search for the anti-amyloid beta drugs using primary neuronal cultures with drebrin cluster density as a marker of synaptic function” Washington DC, USA, October 19-22

Safety Pharmacology Society 14th Annual Meeting, 2014, Yuko Sekino, Mao Ootsu, Yuki Ohara, Hiroyuki Yamazaki, Kaoru Sato, Reiko T Roppongi, Noriko Koganezawa and Tomoaki Shirao, “Effects of valproic acid and astemizole on the neurite growth of human iPSCs-derived neurons” Washington DC, USA, October 19-22

Safety Pharmacology Society 14th Annual Meeting, 2014, Yukari Shigemoto-Mogami, Kanae Ohtsu, Yonehiro Kanemura, Tomoko Shofuda, Hayato Fukusumi, Yohei Okada, Hideyuki Okano, Tomoaki Shirao and Yuko Sekino “Search for the human induced pluripotent stem cell-derived neurons capable of detecting the CNS-specific toxicity” Washington DC, USA, October 19-22

Society for Neuroscience 41th Annual Meeting, 2014, Tomoaki Shirao, Toshiyuki Mizui, Noriko Koganezawa, Hideo Shimizu, Hiroki Yasuda, Yuko Sekino, “Myosin II ATPase activity mediates the biphasic movement of stable F-actin bound by drebrin A between dendritic spines and the parent dendrite in long-term potentiation.” Washington DC, USA, Nov. 15-19

Society for Neuroscience 41th Annual Meeting, 2014, Hiroyuki Yamazaki, Tomoaki Shirao, “Spikar, a novel transcriptional coactivator, regulates the formation and stabilization of dendritic spines dependent on drebrin.” Washington DC, USA, Nov. 15-19

Society for Neuroscience 41th Annual Meeting, 2014, N. KOGANEZAWA, Y. OHARA, H. YAMAZAKI, R. T. ROPPONGI, K. SATO, Y. SEKINO, T. SHIRAO, “Axonal polarity formation in human iPSCs-derived neurons.” Washington DC, USA, Nov. 15-19

Society for Neuroscience 41th Annual Meeting, 2014, Anggraeini Puspitasari, Noriko Koganezawa, Nobuhiko Kojima, Mayu Isono, Yukari Yoshida, Tomoaki Shirao, “Acute effect of X-irradiation and carbon ion-irradiation on fear memory formation and its underlying mechanism.” Washington DC, USA, Nov. 15-19

国内学会

Yuki Ohara, Hiroyuki Yamazaki, Mao Ootsu, Kaoru Sato, Yuko Sekino, Tomoaki Shirao 「Development of human iPSCs-derived neurons.」 第91回日本生理学会大会、鹿児島、2014年3月15日~18日

Yuta Ishizuka, Hideo Shimizu, Eiko Takagi, Tomoaki Shirao「Histone deacetylase (HDAC) inhibitor attenuates amyloid beta-induced synaptic dysfunction」 第87回日本薬理学会年会、仙台、2014年3月19日~21日

白尾智明「培養神経細胞を用いた中枢神経系に対する薬物有害反応試験法開発への課題」第41回日本毒性学会学術年会、神戸、2014年7月2日~4日(invited シンポジウム「ヒトiPS細胞由来分化細胞を用いた医薬品安全性評価の課題と現状」)

Yuta Ishizuka, Hideo Shimizu, Tomoaki Shirao 「Histone deacetylase is involved in the decrease of drebrin cluster density induced by amyloid beta oligomers」第37回日本神経科学大会、横浜、2014年9月11日~13日

Hideo Shimizu, Yuta Ishizuka and Tomoaki Shirao, “Allopregnanolone increases the density of drebrin clusters along dendrite.”第37回日本神経科学大会、横浜、2014年9月11日~13日

Anggraeini Puspitasari, Noriko Koganezawa, Nobuhiko Kojima, Mayu Isono, Yukari Yoshida, Tomoaki Shirao “Acute effect of carbon ion irradiation on hippocampal neuronal cell death and fear memory formation.” 第37回日本神経科学大会、横浜、2014年9月11日~13日

Noriko Koganezawa, Yuki Kajita, Nobuhiko Kojima, Kenji Sakimura and Tomoaki Shirao, “Primary cultured hippocampal neurons prepared from drebrin knockout mouse shows the decrease of MAP2 positive dendrites at late developmental stage.” 第37回日本神経科学大会、横浜、2014年9月11日~13日

Reiko T. Roppongi, Yuki Ohara, Noriko Koganezawa, Hiroyuki Yamazaki, Mao Ootsu, Kaoru Satou, Yuko Sekino, Tomoaki Shirao, “Slow axonal growth in human iPSCs-derived neurons” 第37回日本神経科学大会、横浜、2014年9月11日~13日

Hiroyuki Yamazaki, Tomoaki Shirao, “Spikar function and its stabilization in dendritic spines are dependent on drebrin.” 第37回日本神経科学大会、横浜、2014年9月11日~13日

Yuki Kajita, Nobuhiko Kojima, Kenji Sakimura, Tomoaki Shirao, “Drebrin knockout mice show the olfaction impairment caused by delayed neural exchange in olfactory bulb.” 第37回日本神経科学大会、横浜、2014年9月11日~13日

Hiroyuki Yamazaki, Tomoaki Shirao ”Spikar function and its stabilization in dendritic spines are dependent on drebrin” 第57回日本神経化学大会、奈良、2014年9月29日~10月1日(invited in Symposium “A polyhedral approach to molecular bases involved in synaptic plasticity””

Koganezawa, N., Puspitasari, A., Kojima, N., Isono, M., Yoshida, Y., Shirao, T. “The time-dependent effects of radiation on fear memory and synaptic proteins.” 第57回日本神経化学大会、奈良、2014年9月29日~10月1日(invited in Symposium “The dawn of Radiation Neurobiology”

Tomoaki Shirao, Noriko Koganezawa, Yuki Kajita, Nobuhiko Kojima, Kenji Sakimura. “Primary cultured neurons prepared from drebrin knockout mice have a few MAP2 positive dendrites.”第57回日本神経化学大会、奈良、2014年9月29日~10月1日

清水 英雄、石塚 佑太、白尾 智明「アロプレグナノロンによるドレブリンクラスターと樹状突起スパイン密度の増加効果」第131回日本薬理学会関東部会、横浜、2014年10月11日

 

ページトップへ