脳科学を超えた新しい学問分野を創設する

シナプス成熟とドレブリン

  • Takahashi, H., Sekino, Y., TanakaS., Mizui, T., Kishi, S, and Shirao, T., “Drebrin-dependent Actin Clustering in Dendritic Filopodia Governs Synaptic Targeting of Postsynaptic Density-95 and Dendritic Spine Morphogenesis” J. Neurosci. 23:6586–6595 (2003)
  • Mizui, T., Sekino, Y., Takahashi, H., Yamazaki, H. and Shirao, T. “Overexpression of drebrin A in immature neurons induces the accumulation of F-actin and PSD-95 into dendritic filopodia, and the formation of large abnormal protrusions.” 
    Mol. Cell. Neurosci.  30 (2005) 149-157
  • Aoki, C., Sekino, Y., Hanamura, K., Fujisawa, S., Mahadomrongkul, V., Ren, Y., and Shirao, T. “Drebrin A is a Postsynaptic Protein that Localizes in vivo to the Submembranous Surface of Dendritic Sites Forming Excitatory Synapses”
    J. Comp. Neurol. 483: 383-402 . (2005)
  • Takahashi, H., Mizui, T., Shirao, T. “Downregulation of drebrin A expression suppresses synaptic targeting of NMDA receptors in developing hippocampal neurons” J. Neuochem  97(Suppl.1):110-115 (2006)
  • Fujisawa, S., Shirao, T. Aoki, C. “In vivo, competitive blockade of NMDA receptors induces rapid changes in F-actin and drebrin A distributions within dendritic spines of adult rat cortex.”Neuroscience 140(4):1177-87 (2006)
  • Kobayashi, C., Aoki, C., Kojima, N., Yamazaki, H., and Shirao, T., “Drebrin A content correlates with spine head size in the adult mouse cerebral cortex” J. Comp. Neurol. 503:618-626 (2007)
  • Takahashi, T, Yamazaki, H, Hanamura K, Sekino Y and Shirao T “AMPA receptor inhibition causes abnormal dendritic spines by destabilizing drebrin” J Cell Sci. 122:1211-1229 (2009)
  • Hanamura, K, Mizui T,  Kakizaki T, Roppongi TR, Yamazaki H, Yanagawa Y, Shirao T. “Low accumulation of drebrin at glutamatergic postsynaptic sites on GABAergic neurons” Neuroscience  169: 1489-1500 (2010)
  • Kenichi Kato, Tomoaki Shiraob, Hiroyuki Yamazaki, Kazuyuki Imamura, and Yuko Sekino. “Regulation of AMPA receptor recruitment by the actin binding protein drebrin in cultured hippocampal neurons.” J. Neurosci. Neuroeng. 1: 153-160 (2012)
  • Roppongi RT, Kojima N, Hanamura K, Yamazaki H, Shirao T. “Selective reduction of drebrin and actin in dendritic spines of hippocampal neurons by activation of 5-HT2A receptors.” Neurosci Lett. 547: 76-81 (2013)
  • Mizui T, Sekino Y, Yamazaki1, Yuta Ishizuka H, Takahashi H, Kojima N, Kojima M and ShiraoT. “Myosin II ATPase activity mediates the long-term potentiation-induced exodus of stable F-actin bound by drebrin A from dendritic spines” PLoS ONE. 9(1):e85367 (2014)
  • Yamazaki H, Kojima N, Kato K, Hirose H, Iwasaki T, Mizui T, Takahashi H, Hanamura K,  Roppongi RT, KoibuchiN, Sekino Y, Mori N, Shirao T. “Spikar, a novel drebrin-binding protein, regulates the formation and stabilization of dendritic spines.” J Neurochem. 128:507-522 (2014)

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